Citra folate extraction, specifically the extraction of folate from Organic Citrus Limon, is a new and revolutionary derivation method for folate, also known as vitamin B9. Prior to the introduction of Citra Folate extraction through Organic Citrus Limon, the bioavailability, or absorption, of natural folates ingested from eating whole foods was substantially unreliable when compared to synthetic supplements fortified with oxidized folic acid.
During digestion, a number of factors play a part in the digestion and absorption of folate from whole foods. The basic chemical composition of foods and their reaction to digestive functions can each lower the bioavailability of the vitamin in whole foods.
At the same time, however, synthetic folic acid must undergo a reduction and methylation phase catalyzed by the enzyme dihydrofolate reductase, or DHFR. DHFR has negligible activity in the liver, which may lead to insufficient absorption of folate and could also result in possibly dangerous levels of unmetabolized synthetic folic acid entering the bloodstream. The unmetabolized folic acid present in the bloodstream has been reported to be associated with lower immune function, as there is an inverse relation between unmetabolized folic acid levels in the bloodstream and NK cytotoxicity*.
*Natural Killer cell cytotoxicity is the extent of destructive action an agent (in this case the Natural Killer cell, an immune system cell) can take on an aberrant cell or cells.
Citra folate extraction from Organic Citrus Limon bridges the gap between natural and potentially inefficient whole food folate nutrition and possibly harmful synthetic folic acid supplementation. Sourcing the extraction from whole foods like Organic Citrus Limon minimizes the risk of inadequate absorption and resulting deficiencies while ensuring that complete absorption is taking place and that no unmetabolized folic acid enters the bloodstream.
This extraction prioritizes concentration and purification without the use of added synthetic, isolated folic acid.
Organic Citrus Limon first undergoes a water extraction before an initial basic concentration. The product is then concentrated again but this time through a vacuum and followed by purification. Two rounds of spray drying stabilize the extract before it is powdered and then separated through a sieve. The remaining substance is then analyzed for B vitamins, specifically vitamin B9, or folate, and then 10 to 30% of this extract is used for blending, final analysis, and packaging for a product.
Folate, also known as Vitamin B9, is a commonly used vitamin taken among women who are pregnant or plan to become pregnant as a preventative measure against miscarriage and neural tube birth defects. Spina Bifida, a condition where a baby’s spinal cord fail to develop properly, and anencephaly, a condition in which a baby is born missing part of the skull and brain, both may be averted if a folic acid deficiency is avoided. In addition to the benefits offered to the infant, folate supplementation has been also used to treat anemia and hypertension.